Weakness in one part or side of the body.Patients should stop use and ask a doctor if they have symptoms of heart problems or stroke, including: Patients are directed to ask a doctor before use if they have high blood pressure, heart disease, or have had a stroke. The risk is higher if you use more than directed or for longer than directed.Īccording to the Advil Drug Facts, patients should not use ibuprofen right before or after heart surgery. NSAIDs, except aspirin, increase the risk of heart attack, heart failure, and stroke. Prior history of coronary heart disease or concomitant intake of aspirin did not increase the risk of MI from ibuprofen.Ī case-controlled analysis performed to assess the risk of NSAIDs in relation to acute MI found that ibuprofen did not pose an increased risk of MI. What is the cardiovascular risk associated with low-dose ibuprofen?Ī cohort study that examined 4795 cases of acute MI and death due to coronary heart disease showed the odds ratio for MI for ibuprofen at OTC doses was 1:06 (95% CI, 0.87 to 1.29). Because the effect of aspirin taken daily on platelets is long lasting, the occasional use of ibuprofen poses a minimal risk of attenuating the antiplatelet effect of low-dose aspirin.Taking ibuprofen at least a half hour after the dosing of immediate-release low-dose aspirin is a practical method to minimize potential impairment of the antiplatelet effect of aspirin. However, multiple studies have found that taking ibuprofen or other NSAIDs at Rx doses over prolonged periods can increase the risk of developing cardiovascular events.Īdvil for patients already taking daily low-dose aspirinįor patients already on, or for whom you are considering initiating, a cardioprotective aspirin regimen: Cardiorenal events (high blood pressure, congestive heart failure).Cardiovascular events (myocardial infarction, stroke).Several medical publications have evaluated the cardiovascular safety profile of OTC ibuprofenĪ comprehensive review of existing cardiovascular safety data shows that when ibuprofen is used at OTC doses according to label directions, cardiovascular risk is minimal.ĭata from a series of publications suggest that OTC ibuprofen is not strongly associated with an increased risk of: Cardiovascular: Advil presents minimal cardiovascular risk as observed in clinical studies.Take more than directed or for longer than directed (taking ibuprofen at higher doses than the approved OTC dosing and/or for longer than 10 days also increases this risk).Have a history of stomach bleeding, ulcers, or other bleeding problems.Are taking other drugs containing NSAIDs.Consume 3 or more alcoholic beverages per day.Risk of stomach bleeding increases if patients: Studies have shown that higher doses of ibuprofen (and other NSAIDs) are associated with a greater risk of GI side effects (odds ratio 4:6) vs lower (OTC) doses (odds ratio 1:1)Īs indicated in the Advil Drug Facts, ibuprofen, like all NSAIDs, may cause severe stomach bleeding.In a study by Moore et al, more subjects reported significant digestive adverse events for 1 to 7 days with aspirin (7.1%) or acetaminophen (5.3%) than with ibuprofen (4.0%).An epidemiologic study by Lewis et al and a systematic review by Henry and McGettigan found no significant increased risk of serious upper GI toxicity at dosages A recent literature review of OTC doses of ibuprofen found that there was a consistently low risk of serious GI events and that nonserious GI events are probably reversible upon cessation of the drug. Ibuprofen has a favorable GI safety profile at dosages of 800 mg to 1200 mg per day (at OTC doses).Ĭlinical studies have shown that when OTC ibuprofen is taken as directed by the label for no longer than 10 days, there is a low increased risk of stomach complaints or GI bleeding.
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